Gliclazide impurity F: N-[(perhydro­cyclo­penta­[c]pyrrol-2-yl)amino­carbon­yl]-o-toluene­sulfonamide

نویسندگان

  • Di Wu
  • Xueyuan Wang
  • Dongying Pang
  • Wei Su
  • Yan Sun
چکیده

The title compound, C(15)H(21)N(3)O(3)S, is known to be an impurity of gliclazide [systematic name: N-(hexa-hydro-1H-cyclopenta[c]pyrrol-2-ylcarbamo-yl)-4-methyl-benzene-sulfonamide], a sul-fonyl-urea anti-diabetic drug. Gliclazide has a p-tolyl group substituting the sulfonamide functionality, while the title mol-ecule contains an o-tolyl group. Both five-membered fused rings adopt envelope conformations. In the crystal, N-H⋯O hydrogen bonds are formed between HN(C=O)NH groups, building centrosymmetric dimers. These dimers are further linked through N-H⋯O(sulfon-yl) contacts, forming chains in [100].

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عنوان ژورنال:

دوره 68  شماره 

صفحات  -

تاریخ انتشار 2012