Gliclazide impurity F: N-[(perhydrocyclopenta[c]pyrrol-2-yl)aminocarbonyl]-o-toluenesulfonamide
نویسندگان
چکیده
The title compound, C(15)H(21)N(3)O(3)S, is known to be an impurity of gliclazide [systematic name: N-(hexa-hydro-1H-cyclopenta[c]pyrrol-2-ylcarbamo-yl)-4-methyl-benzene-sulfonamide], a sul-fonyl-urea anti-diabetic drug. Gliclazide has a p-tolyl group substituting the sulfonamide functionality, while the title mol-ecule contains an o-tolyl group. Both five-membered fused rings adopt envelope conformations. In the crystal, N-H⋯O hydrogen bonds are formed between HN(C=O)NH groups, building centrosymmetric dimers. These dimers are further linked through N-H⋯O(sulfon-yl) contacts, forming chains in [100].
منابع مشابه
[(1,3-Benzothiazol-2-yl)aminocarbonyl]methyl piperidine-1-carbodithioate monohydrate
In the title compound, C(15)H(17)N(3)OS(3)·H(2)O, the piperidine ring has a chair conformation. The crystal structure is stabilized by weak inter-molecular N-H⋯O, O-H⋯N and O-H⋯O hydrogen-bonding inter-actions.
متن کاملBis{2-[(1H-pyrrol-2-yl)methyliminomethyl]phenolato-κ2 N,O}zinc(II)
In the title compound, [Zn(C(12)H(11)N(2)O)(2)], the Zn(II) atom, lying on an inversion center, is coordinated by two O atoms and two N atoms from two salicylal Schiff base ligands in a distorted square-planar geometry. A three-dimensional network is formed by inter-molecular C-H⋯N hydrogen bonds and C-H⋯π contacts.
متن کامل2-Methoxyphenyl 2-{2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetamido}acetate
The title compound, amtolmetin guacil, C(24)H(24)N(2)O(5), is a new gastroprotective non-steroidal anti-inflammatory drug. In the crystal structure, the drug mol-ecule is linked into a one-dimensional structure along the c axis by weak N-H⋯O inter-actions between the amide groups. C-H⋯O and C-H⋯π inter-actions influence the packing.
متن کاملDibenzoatobis[3-(pyrrol-1-ylmethyl)pyridine]zinc(II)
In the title compound, [Zn(C(7)H(5)O(2))(2)(C(10)H(10)N(2))(2)], the Zn(II) ion, located on a twofold axis, is coordinated by two N atoms from two 3-(pyrrol-1-ylmeth-yl)pyridine ligands and two O atoms from two benzoate ligands in a distorted tetra-hedral geometry. The pyridine and the pyrrole rings are nearly perpendicular to each other, making a dihedral angle of 84.83 (7)°.
متن کاملN′-[(E)-(1-Methyl-1H-pyrrol-2-yl)methylidene]benzohydrazide
In the title compound, C(13)H(13)N(3)O, the phenyl and pyrrole rings are inclined at 47.45 (8)°. In the crystal, inter-molecular N-H⋯O and C-H⋯O hydrogen bonds form R(2) (1)(6) ring motifs. Mol-ecules connected through these hydrogen bonds are arranged into polymeric chains extending along the c axis.
متن کامل